Chromogranin A is found in almost all endocrine tissues like pituitary, pancreas and parathyroid. This antibody is very useful in IHC to determine whether a tumour has a neuroendocrine origin.

The staining pattern of Chromogranin is Cytoplasmic as shown below.

Picture 1 – Chromogranin positivity in Colon

 

Chromogranin has several different applications. Below are a few examples.

Tumour or cell type	Chromogranin + or -
Medullary Carcinoma of thyroid	Positive
Neuroendocrine tumours	Positive
Neuroblastoma Carcinoma	Positive
Adrenal Caricnoma	Negative