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  • Chromogranin

Chromogranin A is found in almost all endocrine tissues like pituitary, pan reas and parathyroid. very useful in IHC to determine whether a tumour has a neuroendocrine origin.

The staining pattern of Chromogranin is Cytoplasmic as shown below.

Picture 1 – Chromogranin positivity in Colon

 

Chromogranin has several different applications. Below are a few examples.

Tumour or cell type

Chromogranin + or -

Medullary Carcinoma of thyroid

Positive

Neuroendocrine tumours

Positive

Neuroblastoma Carcinoma

Positive

Adrenal Caricnoma

Negative