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  • PSAP

PSAP or Prostatic acid phosphatase is the glandular epithelium of normal, hyperplastic prosate and prosate carcinoma. PSAP similar to PSA can be used to identify tumours origin, whether it originated in the prostate. The staining is more sensitive but is less specific than PSA.

The staining pattern of PSAP is Cytoplasmic as shown below.

Picture 1 – PSAP positivity in Prostate


PSAP has several different applications. Below are a few examples.

Tumour or cell type

PSAP + or -

Prostate Tissue


Prostate Carcinoma


Lung Carcinoma


Breast carcinoma